Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages.\nHowever, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded\nthermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried\noperations of tenofovir (TFV)/Bletilla striata polysaccharide (BSP)/chitosan (CTS) MS were optimized according to the drug\nloading (DL).Thephysicochemical properties of the optimalMS(MS F)were characterized.Depending on the gelation temperature\nand gelating time, the optimal CTS-sodium alginate- (SA-)
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